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Esrrg Gene Detail
Summary
  • Symbol
    Esrrg
  • Name
    estrogen-related receptor gamma
  • Synonyms
    ERR3, Errg, estrogen-related receptor 3, mKIAA0832, NR3B3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347056
    NCBI Gene: 26381
  • Alliance
    genome feature page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:187340988-187947082 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 91.83 cM, cytoband H5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15136 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347056
 protein coding gene Chr1:187340707-187947082 (+)
129S1/SvImJ ENSMUSG00200003204
 protein coding gene Chr1:185112061-185717975 (+)
A/J ENSMUSG00195008212
 protein coding gene Chr1:184685682-185292305 (+)
AKR/J ENSMUSG00220020212
 protein coding gene Chr1:183940391-184546789 (+)
BALB/cJ ENSMUSG00180017423
 protein coding gene Chr1:184758969-185365045 (+)
C3H/HeJ ENSMUSG00175020581
 protein coding gene Chr1:184934371-185540711 (+)
C57BL/6NJ ENSMUSG00215019163
 protein coding gene Chr1:184158442-184764863 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015031
 protein coding gene Chr1:177450623-178056712 (+)
CAST/EiJ ENSTCUG00005041680
 protein coding gene Chr1:182728370-183338111 (+)
CBA/J ENSMUSG00210003389
 protein coding gene Chr1:184613498-185219350 (+)
DBA/2J ENSMUSG00185034492
 protein coding gene Chr1:189226701-189832538 (+)
FVB/NJ ENSMUSG00205003586
 protein coding gene Chr1:183610357-184216957 (+)
JF1/MsJ ENSUMUG00000004287
 protein coding gene Chr1:188183290-188795970 (+)
LP/J ENSMUSG00230023820
 protein coding gene Chr1:188774063-189379854 (+)
NOD/ShiLtJ ENSMUSG00190024438
 protein coding gene Chr1:184592784-185199089 (+)
NZO/HlLtJ ENSMUSG00225009973
 protein coding gene Chr1:192516848-193123201 (+)
PWK/PhJ ENSLUMG00010006196
 protein coding gene Chr1:183442203-184050801 (+)
SPRET/EiJ ENSMSPG00010022822
 protein coding gene Chr1:186980455-187595802 (+)
WSB/EiJ ENSIUOG00005004157
 protein coding gene Chr1:183919276-184527110 (+)



Homology
more
  • Human Ortholog
    ESRRG, estrogen related receptor gamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ESRRG, estrogen related receptor gamma
  • Synonyms
    CONMAE, ERR3, ERRg, ERR-gamma, ERRgamma, NR3B3
  • Links
    NCBI Gene ID: 2104
    UniProt: P62508

  • Chr Location
    1q41; chr1:216503246-217137755 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 5 genetic backgrounds
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations lead to postnatal lethality. Homozygotes for a null allele show reduced birth weight, fasting hyperlactatemia, altered electrocardiograms and mitochondrial function, and agenesis of the renal papilla. Surviving homozygotes for a different null allele exhibit hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1212
  • Tissues
    359
  • cDNA Data
    16
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026610 Ensembl Gene Model | MGI Sequence Detail 606095 C57BL/6J ±  kb
    transcript ENSMUST00000027906 Ensembl | MGI Sequence Detail 5293 Not Applicable  
    polypeptide ENSMUSP00000027906 Ensembl | MGI Sequence Detail 458 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 17
      Primer pair 6
      Other 2
      Antibodies 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 41
      Gene Ontology 14
      Phenotypes 44
    • Earliest
      J:56623 Hong H, et al., Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. J Biol Chem. 1999 Aug 6;274(32):22618-26
    • Latest
      J:391470 Fu H, et al., Multi-layered transcriptional control of glycogen metabolism coordinates thermogenic remodeling of white adipocytes in male mice. Nat Commun. 2025 Dec 16;17(1):809
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory